Soft contact lens extended wear affects corneal epithelial permeability: hypoxic or mechanical etiology?

نویسندگان

  • Meng C Lin
  • Gemma N Soliman
  • Min J Song
  • J Patrick Smith
  • Carolin T Lin
  • Ying Q Chen
  • Kenneth A Polse
چکیده

Contact lens extended wear increases the permeability of epithelium to sodium fluorescein (P(dc)). The exact mechanism is not known. However, changes in P(dc) likely result from either corneal hypoxia or mechanical trauma, or both. We explored the effects of one-night continuous wear with either high- or low-Dk/t soft lenses on P(dc). The results show that corneal epithelial barrier function decreases significantly with both lens groups. We also observed that Asian eyes had higher P(dc) after overnight wear compared to non-Asian and that for both Asian and non-Asian eyes, the elimination of corneal hypoxia did not prevent changes in epithelial permeability.

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عنوان ژورنال:
  • Contact lens & anterior eye : the journal of the British Contact Lens Association

دوره 26 1  شماره 

صفحات  -

تاریخ انتشار 2003